Effect of apple phenols on anxiety/depression in a rat model of acute exacerbation of chronic obstructive pulmonary disease

Figure 3 Contrast the pathological damage of lung tissue in different groups of rats. Hematoxylin and eosin staining, original magnification (× 200). The red arrow: Alveolar atrophy and alveolar wall thickening; the black arrow: Inflammatory cell infiltration. Control: Normal control group; Model: Acute exacerbation of chronic obstructive pulmonary disease model group induced by cigarette smoke and lipopolysaccharide; AP-L: Low-dose apple polyphenols; AP-M: Middle-dose apple polyphenols; AP-H: High-dose apple polyphenols; AP-H + mcc950: High-dose apple polyphenols + NOD-like receptor protein 3 inhibitor.