Effect of apple phenols on anxiety/depression in a rat model of acute exacerbation of chronic obstructive pulmonary disease

Figure 1 Weight changes of rats in each group. Data are presented as mean ± SD (n = 12 per group). ^aP < 0.01 vs control group, ^bP < 0.05 vs model group, ^dP < 0.05 vs low-dose apple polyphenols, ^eP < 0.05 vs middle-dose apple polyphenols. Control: Normal control group; Model: Acute exacerbation of chronic obstructive pulmonary disease model group induced by cigarette smoke and lipopolysaccharide; AP-L: Low-dose apple polyphenols; AP-M: Middle-dose apple polyphenols; AP-H: High-dose apple polyphenols; AP-H + mcc950: High-dose apple polyphenols + NOD-like receptor protein 3 inhibitor.