Double-edged sword of antipsychotic therapy: Navigating the intersection of psychiatric recovery, endoplasmic reticulum stress, and cardiovascular survival

doi:10.5498/wjp.v16.i6.118149

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 6

This Article

(26)

(23)

(0)

(36)

(403)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Psychiatry

ISSN

2220-3206

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Opinion Review

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jun 19, 2026; 16(6): 118149
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.118149

Table 1 Relationship between antipsychotic drug prescriptions and mortality rates

Study metric	No antipsychotic use	Any antipsychotics	Clozapine
All-cause mortality (aHR)	1.00 (reference)	0.48	0.39
Cardiovascular mortality (aHR)	1.00 (reference)	0.62	0.55
Suicide mortality (aHR)	1.00 (reference)	0.52	0.21
20-year cumulative mortality (%)	46.2	25.7	15.6

Adjusted hazard ratios are based on the Finnish nationwide cohort[38]. A lower ratio indicates a higher protective effect compared to non-use. aHR: Adjusted hazard ratios.

Full Size Table

Citation: Nagamine T. Double-edged sword of antipsychotic therapy: Navigating the intersection of psychiatric recovery, endoplasmic reticulum stress, and cardiovascular survival. World J Psychiatry 2026; 16(6): 118149
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/118149.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.118149