Thyroid-stimulating hormone levels and suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder

doi:10.5498/wjp.v16.i6.116435

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Observational Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jun 19, 2026; 16(6): 116435
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.116435

Table 4 Thyroid dysfunction prevalence, n (%)

Condition	Overall	Non-SA	SA
Subclinical hypothyroidism (TSH > 4.20 μIU/mL with normal FT4/FT3)	1034 (60.19)	771 (56.20)	263 (76.01)
Overt hypothyroidism (TSH > 10 μIU/mL with low FT4/FT3)	0 (0.00)	0 (0.00)	0 (0.00)

Thyroid dysfunction was defined using combined thyroid-stimulating hormone (TSH) and thyroid hormone criteria. Subclinical hypothyroidism was defined as TSH > 4.20 μIU/mL with free thyroxine and free triiodothyronine within the reference ranges. Overt hypothyroidism was defined as TSH > 10 μIU/mL with free thyroxine and/or free triiodothyronine below the lower limits of the reference ranges. FT3: Free triiodothyronine; FT4: Free thyroxine; SA: Suicide attempt; TSH: Thyroid-stimulating hormone.

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Citation: Deng HX, Liu YZ, Yang L, Liu JJ, Jia FN, Zhao XL, Xia XZ, Zhang XY, Du XD. Thyroid-stimulating hormone levels and suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder. World J Psychiatry 2026; 16(6): 116435
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/116435.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.116435

Deng HX, Liu YZ, Yang L, Liu JJ, Jia FN, Zhao XL, Xia XZ, Zhang XY, Du XD. Thyroid-stimulating hormone levels and suicide attempts in Chinese patients with first-episode drug-naïve major depressive disorder. World J Psychiatry 2026; 16(6): 116435 [DOI: 10.5498/wjp.v16.i6.116435]

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