Beyond vision: The overlooked burden of depression in glaucoma patients

doi:10.5498/wjp.v16.i6.116408

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jun 19, 2026; 16(6): 116408
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.116408

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Figure 1 Risk factors for glaucoma and depression. Glaucoma and depression are linked by epidemiology (higher prevalence, bidirectional risk), psychosocial factors (fear of blindness, role loss, and social isolation), neurobiological mechanisms (hypothalamic-pituitary-adrenal-axis dysregulation, neuroinflammation, mitochondrial dysfunction, reduced brain-derived neurotrophic factor), and treatment burden. Clinicians see low adherence and inferior outcomes from these domains. Arrows show relationships, not causes. HPA: Hypothalamic-pituitary-adrenal; BDNF: Brain-derived neurotrophic factor.

Citation: Capobianco M, Cappellani F, Khouyyi M, Nicolosi SG, D’Esposito F, Musa M, Battista M, Barboni P, Gagliano C, Zeppieri M. Beyond vision: The overlooked burden of depression in glaucoma patients. World J Psychiatry 2026; 16(6): 116408
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/116408.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.116408

Capobianco M, Cappellani F, Khouyyi M, Nicolosi SG, D’Esposito F, Musa M, Battista M, Barboni P, Gagliano C, Zeppieri M. Beyond vision: The overlooked burden of depression in glaucoma patients. World J Psychiatry 2026; 16(6): 116408 [DOI: 10.5498/wjp.v16.i6.116408]

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