Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction

doi:10.5498/wjp.v16.i6.115917

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World Journal of Psychiatry

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2220-3206

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World J Psychiatry. Jun 19, 2026; 16(6): 115917
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.115917

Table 8 Generalized estimating equation analysis of depression symptom treatment response among different age groups

Effect	Wald χ²	df	P value
Time	42.158	3	< 0.001
Age group	28.347	2	< 0.001
Time × age group	16.842	6	0.010
NIHSS score	12.546	1	< 0.001
MMSE score	9.327	1	0.002
hs-CRP	6.184	1	0.013
Infarct size	4.832	1	0.028
Baseline depression score	8.746	1	0.003

Contrast estimates (reference: Young group): (1) Middle-aged vs young group: β = 1.74, SE = 0.48, P < 0.001; (2) Elderly vs young group: β = 3.21, SE = 0.67, P < 0.001; and (3) Middle-aged vs elderly group: β = -1.47, SE = 0.56, P = 0.009. NIHSS: National Institutes of Health Stroke Scale; hs-CRP: High-sensitivity C-reactive protein; MMSE: Mini-Mental State Examination.

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Citation: Li JJ, Chen ZJ, Nian WH, Liang YL, Su WJ. Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction. World J Psychiatry 2026; 16(6): 115917
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/115917.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.115917

Li JJ, Chen ZJ, Nian WH, Liang YL, Su WJ. Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction. World J Psychiatry 2026; 16(6): 115917 [DOI: 10.5498/wjp.v16.i6.115917]

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