Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction

doi:10.5498/wjp.v16.i6.115917

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jun 19, 2026; 16(6): 115917
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.115917

Table 6 Functional status assessment results among different age groups, mean ± SD

Time point	Young group (n = 68)	Middle-aged group (n = 124)	Elderly group (n = 108)	F value	P value
Barthel index
At discharge	65.8 ± 19.2	58.4 ± 21.5	48.6 ± 24.1	14.273	< 0.001
1-month post-discharge	76.2 ± 17.4	67.8 ± 20.1	54.9 ± 23.8	21.847	< 0.001
3-month post-discharge	84.5 ± 15.8	74.2 ± 18.6	61.3 ± 22.4	31.526	< 0.001
6-month post-discharge	88.7 ± 13.2	78.9 ± 17.1	65.8 ± 21.6	36.841	< 0.001
mRS score
At discharge	2.6 ± 1.4	3.1 ± 1.5	3.4 ± 1.6	6.847	0.001
1-month post-discharge	2.2 ± 1.3	2.9 ± 1.4	3.1 ± 1.5	9.184	< 0.001
3-month post-discharge	1.8 ± 1.1	2.5 ± 1.3	2.8 ± 1.4	15.657	< 0.001
6-month post-discharge	1.6 ± 1.0	2.3 ± 1.2	2.6 ± 1.3	18.294	< 0.001

Repeated measures analysis of variance results: (1) Barthel index: Time effect F = 124.367, P < 0.001; between-group effect F = 38.156, P < 0.001; time × group interaction effect F = 9.584, P < 0.001; and (2) Modified Rankin Scale score: Time effect F = 67.429, P < 0.001; between-group effect F = 41.283, P < 0.001; time × group interaction effect F = 6.847, P < 0.001. mRS: Modified Rankin Scale.

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Citation: Li JJ, Chen ZJ, Nian WH, Liang YL, Su WJ. Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction. World J Psychiatry 2026; 16(6): 115917
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/115917.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.115917

Li JJ, Chen ZJ, Nian WH, Liang YL, Su WJ. Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction. World J Psychiatry 2026; 16(6): 115917 [DOI: 10.5498/wjp.v16.i6.115917]

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