Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction

doi:10.5498/wjp.v16.i6.115917

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jun 19, 2026; 16(6): 115917
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.115917

Table 2 Comparison of medication history and clinical characteristics among different age groups, mean ± SD/n (%)

Item	Young group (n = 68)	Middle-aged group (n = 124)	Elderly group (n = 108)	χ²/F value	P value
Medication history
Anticoagulants	8 (11.8)	28 (22.6)	45 (41.7)	17.842	< 0.001
Antihypertensive drugs	26 (38.2)	74 (59.7)	86 (79.6)	24.567	< 0.001
Antidiabetic drugs	10 (14.7)	32 (25.8)	44 (40.7)	12.985	0.002
Lipid-lowering drugs	15 (22.1)	38 (30.6)	42 (38.9)	5.234	0.073
Clinical characteristics
Onset to admission time (hours)	16.8 ± 11.2	20.4 ± 14.9	26.7 ± 18.3	8.254	< 0.001
Initial symptoms				8.942	0.063
Limb weakness	45 (66.2)	89 (71.8)	85 (78.7)
Speech disorders	18 (26.5)	28 (22.6)	18 (16.7)
Others	5 (7.4)	7 (5.6)	5 (4.6)
Imaging characteristics
Large infarct (> 1/3 middle cerebral artery territory)	12 (17.6)	28 (22.6)	35 (32.4)	5.847	0.054
Involvement of key areas	15 (22.1)	35 (28.2)	42 (38.9)	6.234	0.044
TOAST classification				7.865	0.248
Large-artery atherosclerosis	28 (41.2)	56 (45.2)	54 (50.0)
Small-vessel occlusion	24 (35.3)	42 (33.9)	32 (29.6)
Cardioembolism	8 (11.8)	16 (12.9)	18 (16.7)
Other causes	8 (11.8)	10 (8.1)	4 (3.7)

TOAST: Trial of org 10172 in acute stroke treatment.

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Citation: Li JJ, Chen ZJ, Nian WH, Liang YL, Su WJ. Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction. World J Psychiatry 2026; 16(6): 115917
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/115917.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.115917

Li JJ, Chen ZJ, Nian WH, Liang YL, Su WJ. Age-stratified analysis of depression onset patterns and treatment response differences following cerebral infarction. World J Psychiatry 2026; 16(6): 115917 [DOI: 10.5498/wjp.v16.i6.115917]

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