Association between vascular risk factor clustering and post-stroke depression

doi:10.5498/wjp.v16.i6.114616

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jun 19, 2026; 16(6): 114616
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.114616

Table 1 Baseline characteristics of study subjects, n (%)

Characteristics	Total (n = 110)	Low-risk group (≤ 2 factors) (n = 52)	High-risk group (≥ 3 factors) (n = 58)	Test statistic	P value
Demographics
Age (years), mean ± SD	67.3 ± 10.2	66.5 ± 10.8	68.0 ± 9.7	t = -0.762	0.448
Age range (years)	45-84	45-82	48-84	-	-
Male gender	64 (58.2)	30 (57.7)	34 (58.6)	χ² = 0.009	0.924
Female gender	46 (41.8)	22 (42.3)	24 (41.4)	χ² = 0.009	0.924
Clinical assessment
NIHSS score, median (range)	6 (2-16)	6 (2-15)	7 (2-16)	Z = -1.152	0.249
Vascular risk factors
Hypertension	86 (78.2)	32 (61.5)	54 (93.1)	χ² = 15.674	< 0.001
Dyslipidemia	76 (69.1)	28 (53.8)	48 (82.8)	χ² = 10.234	0.001
Diabetes mellitus	50 (45.5)	14 (26.9)	36 (62.1)	χ² = 13.045	< 0.001
Smoking history	48 (43.6)	15 (28.8)	33 (56.9)	χ² = 8.567	0.003
Coronary heart disease	40 (36.4)	7 (13.5)	33 (56.9)	χ² = 21.459	< 0.001
Drinking history	32 (29.1)	8 (15.4)	24 (41.4)	χ² = 8.673	0.003
Atrial fibrillation	20 (18.2)	4 (7.7)	16 (27.6)	χ² = 7.236	0.007

NIHSS: National Institutes of Health Stroke Scale.

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Citation: Zhao JD, Yu CW, Lin KY, Huang JL, Qiu SW. Association between vascular risk factor clustering and post-stroke depression. World J Psychiatry 2026; 16(6): 114616
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/114616.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.114616

Zhao JD, Yu CW, Lin KY, Huang JL, Qiu SW. Association between vascular risk factor clustering and post-stroke depression. World J Psychiatry 2026; 16(6): 114616 [DOI: 10.5498/wjp.v16.i6.114616]

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