Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation

doi:10.5498/wjp.v16.i6.114553

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jun 19, 2026; 16(6): 114553
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.114553

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Figure 5 Transcriptomics analysis of the colonic tissues from rats. A: The volcano plot of the differentially expressed genes (DEGs) from Guipi pills vs chronic unpredictable mild stress model group; B: The heatmap of the DEGs from Guipi pills vs chronic unpredictable mild stress model group; C: Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the up-regulated DEGs; D: Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the down-regulated DEGs. CUMS: Chronic unpredictable mild stress; GPP: Guipi pills; KEGG: Kyoto Encyclopedia of Genes and Genomes.

Citation: Zhong J, Chen W, Li S, Zheng DL, Wang YD, Huang JH, Liang XQ, Liang MK. Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation. World J Psychiatry 2026; 16(6): 114553
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/114553.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.114553

Zhong J, Chen W, Li S, Zheng DL, Wang YD, Huang JH, Liang XQ, Liang MK. Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation. World J Psychiatry 2026; 16(6): 114553 [DOI: 10.5498/wjp.v16.i6.114553]

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