Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation

Figure 3 Animal behavioral test. A: Representative trajectory plots of rats in the open field test; B and C: Total distance and central distance traveled by rats in the open field test; D and E: Morris water maze experiment (spatial exploration experiment). ^aP < 0.05 vs control; ^bP < 0.05 vs chronic unpredictable mild stress model; ^cP < 0.01 vs chronic unpredictable mild stress model; ^dP < 0.01 vs control. CUMS: Chronic unpredictable mild stress; FH: Fluoxetine hydrochloride; GPP-L: Guipi pills-low dose; GPP-M: Guipi pills-medium dose; GPP-H: Guipi pills-high dose.