Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation

doi:10.5498/wjp.v16.i6.114553

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jun 19, 2026; 16(6): 114553
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.114553

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Figure 1 Schematic illustration of the study flow. GEO: Gene Expression Omnibus; MDD: Major depressive disorder; IBD: Inflammatory bowel disease; DEGs: Differentially expressed genes; eQTL: Expression quantitative trait loci; PBMC: Peripheral blood mononuclear cell; LD: Linkage disequilibrium; CUMS: Chronic unpredictable mild stress; OFT: Open field test; WMT: Water maze test; IVW: Inverse-variance weighted; MR: Mendelian randomization; MR-PRESSO: MR-pleiotropy residual sum and outlier; GZMA: Granzyme A.

Citation: Zhong J, Chen W, Li S, Zheng DL, Wang YD, Huang JH, Liang XQ, Liang MK. Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation. World J Psychiatry 2026; 16(6): 114553
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/114553.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.114553

Zhong J, Chen W, Li S, Zheng DL, Wang YD, Huang JH, Liang XQ, Liang MK. Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation. World J Psychiatry 2026; 16(6): 114553 [DOI: 10.5498/wjp.v16.i6.114553]

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