Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation

doi:10.5498/wjp.v16.i6.114553

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Jun 19, 2026; 16(6): 114553
Published online Jun 19, 2026. doi: 10.5498/wjp.v16.i6.114553

Table 5 Mendelian randomization analysis of the genes GZMA, GZMK, and KCNJ2

Gene	NSNP	Method	B	SE	OR	OR_lci95	OR_uci95	P value
GZMA	7	MR Egger	-0.09239	0.078431	0.911751	0.781834	1.063256	0.291817
GZMA	7	Weighted median	-0.08458	0.053111	0.918895	0.82805	1.019706	0.111255
GZMA	7	Inverse variance weighted	-0.12065	0.041886	0.886347	0.816488	0.962183	0.003972
GZMA	7	Simple mode	-0.21042	0.087087	0.810241	0.683101	0.961046	0.052129
GZMA	7	Weighted mode	-0.07722	0.058268	0.925688	0.825784	1.037679	0.233323
GZMK	11	MR Egger	-0.02138	0.083978	0.978844	0.830291	1.153977	0.804737
GZMK	11	Weighted median	-0.01697	0.034472	0.983177	0.918942	1.051902	0.622597
GZMK	11	Inverse variance weighted	-0.00035	0.030074	0.999651	0.94243	1.060346	0.990735
GZMK	11	Simple mode	0.069455	0.064164	1.071923	0.945248	1.215574	0.304464
GZMK	11	Weighted mode	-0.02461	0.038771	0.975686	0.90429	1.052719	0.539766
KCNJ2	10	MR Egger	-0.0695	0.060344	0.932864	0.828805	1.049987	0.28271
KCNJ2	10	Weighted median	-0.05446	0.037879	0.946994	0.879234	1.019977	0.150487
KCNJ2	10	Inverse variance weighted	-0.05834	0.03037	0.943326	0.888812	1.001183	0.054721
KCNJ2	10	Simple mode	-0.04438	0.05821	0.956592	0.853448	1.072201	0.465342
KCNJ2	10	Weighted mode	-0.05748	0.042219	0.944141	0.869159	1.025592	0.206474

NSNP: Number of single nucleotide polymorphism; OR: Odds ratio.

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Citation: Zhong J, Chen W, Li S, Zheng DL, Wang YD, Huang JH, Liang XQ, Liang MK. Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation. World J Psychiatry 2026; 16(6): 114553
URL: https://www.wjgnet.com/2220-3206/full/v16/i6/114553.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i6.114553

Zhong J, Chen W, Li S, Zheng DL, Wang YD, Huang JH, Liang XQ, Liang MK. Exploring the antidepressant mechanisms of Guipi pill: A focus on gut-brain axis and immunity modulation. World J Psychiatry 2026; 16(6): 114553 [DOI: 10.5498/wjp.v16.i6.114553]

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