Meta-analysis of dopaminergic-serotonergic modulation strategies for depressive symptoms in Parkinson’s disease

doi:10.5498/wjp.v16.i5.115867

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Meta-Analysis

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. May 19, 2026; 16(5): 115867
Published online May 19, 2026. doi: 10.5498/wjp.v16.i5.115867

Table 3 Summary effect sizes and heterogeneity analysis of each major outcome indicator

Reproductive outcomes	Number of studies	WMD/RR 95%CI	P value	I²
Improving depression	3	1.35 (1.15-1.60)	< 0.001	0%
Quality of life	2	-2.41 (-3.02 to -1.79)	< 0.001	0%
Motor function	4	-0.75 (-0.91 to -0.59)	< 0.001	80.9%
Adverse event	5	1.61 (0.82-3.19)	0.169	0%

WMD: Weighted mean difference; RR: Relative risk; CI: Confidence interval.

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Citation: Li CC, Zhou Y, Chen KX, Zhang L, Gu WL, Gu H. Meta-analysis of dopaminergic-serotonergic modulation strategies for depressive symptoms in Parkinson’s disease. World J Psychiatry 2026; 16(5): 115867
URL: https://www.wjgnet.com/2220-3206/full/v16/i5/115867.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i5.115867

Li CC, Zhou Y, Chen KX, Zhang L, Gu WL, Gu H. Meta-analysis of dopaminergic-serotonergic modulation strategies for depressive symptoms in Parkinson’s disease. World J Psychiatry 2026; 16(5): 115867 [DOI: 10.5498/wjp.v16.i5.115867]

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