Meta-analysis of dopaminergic-serotonergic modulation strategies for depressive symptoms in Parkinson’s disease

Table 1 Risk assessment and quality evaluation of literature bias

Ref.	Type	Random sequence generation	Distribution concealment	Blind implementation	Missing data	Selective reporting	Risk type of bias	Risk score (0-10)	Quality score (Jadad)
Barone et al[10], 2010	RCT	+	+	+	+	+	Low risk	9	5
Menza et al[11], 2009	RCT	?	?	-	?	?	Moderate risk	5	3
Rektorova et al[12], 2008	RCT	-	-	-	-	-	High-risk	2	2
Weintraub et al[13], 2010	RCT	?	?	-	?	?	Moderate risk	5	3
Devos et al[14], 2008	RCT	+	+	+	+	?	Low risk	8	5

According to the specific performance in the study, each risk factor was divided into low risk (“+”), high risk (“-”) and unclear (“?”). RCT: Randomized controlled trial.