Anxiety, depression, and quality of life in hepatocellular carcinoma treated with drug-eluting microspheres plus lenvatinib: A prospective study

doi:10.5498/wjp.v16.i4.116158

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Apr 19, 2026; 16(4): 116158
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.116158

Table 5 Treatment-related adverse events (n = 126), n (%)

AEs	Any grade	Grade 1 or 2	Grade ≥ 3
Post-embolization syndrome	105 (83.3)	105 (83.3)	0 (0)
Hypertension	60 (47.6)	48 (38.1)	12 (9.5)
Reduced appetite	54 (42.9)	52 (41.3)	2 (1.6)
Fatigue	48 (38.1)	45 (35.7)	3 (2.4)
Diarrhea	44 (34.9)	43 (34.1)	1 (0.8)
Hand-foot skin reaction	40 (31.7)	38 (30.2)	2 (1.6)
Elevated AST/ALT	38 (30.2)	30 (23.8)	8 (6.3)
Nausea	36 (28.6)	36 (28.6)	0 (0)
Proteinuria	28 (22.2)	23 (18.3)	5 (4.0)
Thrombocytopenia	24 (19.0)	20 (15.9)	4 (3.2)
Dysphonia	22 (17.5)	22 (17.5)	0 (0)
Abdominal pain	20 (15.9)	20 (15.9)	0 (0)
Weight loss	18 (14.3)	18 (14.3)	0 (0)
Hypothyroidism	14 (11.1)	14 (11.1)	0 (0)

AE: Adverse event; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase.

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Citation: Liu JY, Liang ZH, Liu JL, Li L, Cui B, Li TG. Anxiety, depression, and quality of life in hepatocellular carcinoma treated with drug-eluting microspheres plus lenvatinib: A prospective study. World J Psychiatry 2026; 16(4): 116158
URL: https://www.wjgnet.com/2220-3206/full/v16/i4/116158.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i4.116158

Liu JY, Liang ZH, Liu JL, Li L, Cui B, Li TG. Anxiety, depression, and quality of life in hepatocellular carcinoma treated with drug-eluting microspheres plus lenvatinib: A prospective study. World J Psychiatry 2026; 16(4): 116158 [DOI: 10.5498/wjp.v16.i4.116158]

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