Chinese herbal formulas alleviated depression in breast cancer patients: A meta-analysis, network pharmacology and experimental validation

Figure 5 Network pharmacology analysis for Si-Ni-San in the anti-depression treatment of breast cancer. A: Preclinical evidence of Si-Ni-San in suppressing breast tumor growth and metastasis induced by chronic psychological stress; B: The intersection of target genes involved in top five herbs, breast cancer and depression; C: Protein-protein-interaction network analysis of the common target genes; D: Biological process enrichment analysis of the common target genes; E: Molecular function enrichment analysis of the common target genes; F: Cellular component enrichment analysis of the common target genes; G: Kyoto Encyclopedia of Genes and Genomes enrichment analysis of the common target genes. CSCs: Cancer stem cells.