Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma

doi:10.5498/wjp.v16.i4.115490

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Apr 19, 2026; 16(4): 115490
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.115490

Table 9 Receiver operating characteristic curve analysis of immune indicators for predicting depressive symptoms

Indicator	AUC	95%CI	P value	Optimal cutoff value	Sensitivity	Specificity	Youden index
IL-6 (pg/mL)	0.782	0.719-0.844	< 0.001	6.35	71.7	75.3	0.470
CD4+ cell count (cells/μL)	0.731	0.664-0.798	< 0.001	798	69.0	70.8	0.398
NLR	0.698	0.627-0.769	< 0.001	2.65	66.4	67.4	0.338
TNF-α (pg/mL)	0.682	0.609-0.754	< 0.001	16.8	63.7	68.5	0.322
CRP (mg/L)	0.671	0.598-0.744	< 0.001	8.9	61.9	66.3	0.282

AUC: Area under the curve; CI: Confidence interval; IL-6: Interleukin-6; NLR: Neutrophil-to-lymphocyte ratio; TNF-α: Tumor necrosis factor-α; CRP: C-reactive protein.

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Citation: Dong S, Mou HL, Zhang H, Ye T. Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma. World J Psychiatry 2026; 16(4): 115490
URL: https://www.wjgnet.com/2220-3206/full/v16/i4/115490.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i4.115490

Dong S, Mou HL, Zhang H, Ye T. Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma. World J Psychiatry 2026; 16(4): 115490 [DOI: 10.5498/wjp.v16.i4.115490]

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