Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma

doi:10.5498/wjp.v16.i4.115490

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Apr 19, 2026; 16(4): 115490
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.115490

Table 7 Correlation analysis of Patient Health Questionnaire-9 scores and immune function indicators

Indicator	Correlation coefficient (r)	P value	Correlation type
CD3+ cell count	-0.312	< 0.001	Spearman
CD4+ cell count	-0.367	< 0.001	Spearman
CD4+/CD8+ ratio	-0.289	< 0.001	Pearson
NK cell count	-0.298	< 0.001	Pearson
Complement C3	-0.245	0.001	Pearson
Complement C4	-0.263	< 0.001	Pearson
IL-6	0.456	< 0.001	Spearman
TNF-α	0.398	< 0.001	Spearman
IL-10	-0.287	< 0.001	Pearson
IFN-γ	-0.324	< 0.001	Pearson
CRP	0.372	< 0.001	Spearman
ESR	0.335	< 0.001	Spearman
NLR	0.418	< 0.001	Spearman
Lymphocyte count	-0.356	< 0.001	Pearson
Albumin	-0.294	< 0.001	Pearson

NK: Natural killer; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-α; IL-10: Interleukin-10; IFN-γ: Interferon-γ; CRP: C-reactive protein; ESR: Erythrocyte sedimentation rate; NLR: Neutrophil-to-lymphocyte ratio.

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Citation: Dong S, Mou HL, Zhang H, Ye T. Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma. World J Psychiatry 2026; 16(4): 115490
URL: https://www.wjgnet.com/2220-3206/full/v16/i4/115490.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i4.115490

Dong S, Mou HL, Zhang H, Ye T. Correlation analysis of depressive symptoms and immune function indicators in patients with malignant melanoma. World J Psychiatry 2026; 16(4): 115490 [DOI: 10.5498/wjp.v16.i4.115490]

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