Monitoring white matter volume alterations via cranial magnetic resonance imaging in major depressive disorder: Association with cognitive dysfunction

doi:10.5498/wjp.v16.i4.115192

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Apr 19, 2026; 16(4): 115192
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.115192

Table 3 Intergroup differences on neuropsychological assessments, mean ± SD

	Observation group (n = 86)	Control group (n = 50)	t value	P value
MoCA	19.22 ± 1.88	28.30 ± 0.68	32.88	< 0.0001
TMT-A (second)	69.51 ± 17.23	53.36 ± 14.64	5.561	< 0.0001
TMT-B (second)	106.97 ± 33.27	87.90 ± 6.28	10.31	< 0.0001
DSST	57.56 ± 10.07	44.16 ± 8.19	7.993	< 0.0001

MoCA: Montreal Cognitive Assessment; TMT-A: Trail Making Test Part A; TMT-B: Trail Making Test Part B; DSST: Digit Symbol Substitution Test.

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Citation: Liu L, Tang S, Chen MZ, Nie X, Li J, Yao L, Zeng BG, Zhou JB, Zhou FQ. Monitoring white matter volume alterations via cranial magnetic resonance imaging in major depressive disorder: Association with cognitive dysfunction. World J Psychiatry 2026; 16(4): 115192
URL: https://www.wjgnet.com/2220-3206/full/v16/i4/115192.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i4.115192

Liu L, Tang S, Chen MZ, Nie X, Li J, Yao L, Zeng BG, Zhou JB, Zhou FQ. Monitoring white matter volume alterations via cranial magnetic resonance imaging in major depressive disorder: Association with cognitive dysfunction. World J Psychiatry 2026; 16(4): 115192 [DOI: 10.5498/wjp.v16.i4.115192]

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