Serum 5-hydroxytryptamine levels as biomarkers for motor dysfunction and depression in Parkinson’s disease patients

doi:10.5498/wjp.v16.i4.114462

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World Journal of Psychiatry

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2220-3206

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Apr 19, 2026; 16(4): 114462
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.114462

Table 3 Correlation analysis between 5-hydroxytryptamine levels and clinical variables

Variable	r	P value
Disease duration	-0.358	0.002^b
H-Y staging	-0.312	0.008^b
UPDRS I	-0.445	< 0.001^c
UPDRS III	-0.267	0.025^a
Duration of dopaminergic treatment	-0.389	0.001^b
Duration of wearing-off episodes	-0.512	< 0.001^c
Duration of on-off phenomena	-0.478	< 0.001^c
Maximum daily levodopa dose	-0.334	0.005^b
Age at disease onset	0.298	0.012^a
Current age	0.156	0.196
PDQ-39 total score	-0.567	< 0.001^c
PDQ-39 emotional well-being	-0.612	< 0.001^c

^aP < 0.05.

^bP < 0.01.

^cP < 0.001.

H-Y: Hoehn-Yahr; UPDRS: Unified Parkinson’s Disease Rating Scale; PDQ-39: Parkinson’s Disease Questionnaire 39.

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Citation: Chen YS, Yang SY, Lu KY, Li M, Liu T, Zhu SG, Lu HL, Hu K. Serum 5-hydroxytryptamine levels as biomarkers for motor dysfunction and depression in Parkinson’s disease patients. World J Psychiatry 2026; 16(4): 114462
URL: https://www.wjgnet.com/2220-3206/full/v16/i4/114462.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i4.114462

Chen YS, Yang SY, Lu KY, Li M, Liu T, Zhu SG, Lu HL, Hu K. Serum 5-hydroxytryptamine levels as biomarkers for motor dysfunction and depression in Parkinson’s disease patients. World J Psychiatry 2026; 16(4): 114462 [DOI: 10.5498/wjp.v16.i4.114462]

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