Risk characteristics of obesity and atherosclerotic cardiovascular events in patients with schizophrenia: A single-center 10-year retrospective cohort study

Table 7 Multivariable predictors of major adverse cardiovascular events in our hospital cohort

Predictor	Adjusted hazard ratios (95% confidence interval)	P value
Demographic factors
Age (per 10 years)	1.42 (1.35-1.49)	< 0.001
Male sex	1.34 (1.21-1.48)	< 0.001
Black race (vs White)	1.23 (1.09-1.39)	0.001
Traditional CV risk factors
Obesity (BMI ≥ 30)	2.34 (2.11-2.59)	< 0.001
Diabetes mellitus	2.12 (1.89-2.37)	< 0.001
Hypertension	1.78 (1.60-1.98)	< 0.001
Dyslipidemia	1.56 (1.41-1.73)	< 0.001
Current smoking	1.67 (1.51-1.85)	< 0.001
Psychiatric factors
Duration at our facility (per year)	1.03 (1.02-1.04)	< 0.001
Hospitalizations (per admission)	1.08 (1.05-1.11)	< 0.001
Negative symptom severity	1.12 (1.06-1.18)	< 0.001
Medication factors
Antipsychotic polypharmacy	1.67 (1.49-1.87)	< 0.001
High metabolic risk AP	1.89 (1.68-2.13)	< 0.001
CPZ equivalent dose (per 100 mg)	1.09 (1.05-1.13)	< 0.001

CV: Cardiovascular; BMI: Body mass index; AP: Antipsychotic; CPZ: Chlorpromazine.