Risk characteristics of obesity and atherosclerotic cardiovascular events in patients with schizophrenia: A single-center 10-year retrospective cohort study

Table 6 Metabolic parameter changes over 10-year follow-up at our institution, n (%)/mean ± SD

Parameter	Baseline	Year 2	Year 5	Year 10	P value
Weight and BMI
Mean weight, kg	84.3 ± 19.2	89.1 ± 20.4	91.2 ± 21.3	92.8 ± 22.1	< 0.001
Mean BMI, kg/m2	29.8 ± 6.4	31.5 ± 6.8	32.2 ± 7.1	32.8 ± 7.4	< 0.001
Obesity prevalence, %	43.7	52.3	58.4	62.1	< 0.001
Metabolic syndrome
Prevalence, %	38.9	46.2	52.8	58.3	< 0.001
Mean components, n	2.3 ± 1.4	2.7 ± 1.4	3.0 ± 1.4	3.2 ± 1.3	< 0.001
Glycemic control
Mean fasting glucose, mg/dL	108.3 ± 32.4	112.4 ± 34.8	115.8 ± 36.2	118.9 ± 38.4	< 0.001
Mean HbA1c, %	6.1 ± 1.3	6.3 ± 1.4	6.5 ± 1.5	6.7 ± 1.6	< 0.001
Diabetes prevalence, %	18.4	24.3	29.8	34.2	< 0.001
Lipid profile
Mean LDL, mg/dL	118.2 ± 35.4	121.3 ± 36.2	123.8 ± 37.1	125.4 ± 37.8	< 0.001
Mean HDL, mg/dL	44.3 ± 13.2	43.1 ± 12.8	42.2 ± 12.5	41.4 ± 12.3	< 0.001
Mean triglycerides, mg/dL	178.4 ± 98.3	186.2 ± 102.4	192.8 ± 106.3	198.4 ± 109.2	< 0.001

BMI: Body mass index; HbA1c: Hemoglobin A1c; LDL: Low-density lipoprotein; HDL: High-density lipoprotein.