Risk characteristics of obesity and atherosclerotic cardiovascular events in patients with schizophrenia: A single-center 10-year retrospective cohort study

doi:10.5498/wjp.v16.i4.114138

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Apr 19, 2026; 16(4): 114138
Published online Apr 19, 2026. doi: 10.5498/wjp.v16.i4.114138

Table 1 Baseline demographic and clinical characteristics of our hospital cohort, n (%)/mean ± SD

Characteristic	Total cohort (n = 10000)	Obese (n = 4370)	Non-obese (n = 5630)	P value
Demographics
Age, years	42.3 ± 13.5	44.1 ± 12.8	40.9 ± 13.9	< 0.001
Male sex	5820 (58.2)	2234 (51.1)	3586 (63.7)	< 0.001
Race/ethnicity				0.002
White	4235 (42.4)	1789 (40.9)	2446 (43.4)
Black	2890 (28.9)	1342 (30.7)	1548 (27.5)
Hispanic	1876 (18.8)	856 (19.6)	1020 (18.1)
Asian	654 (6.5)	234 (5.4)	420 (7.5)
Other	345 (3.5)	149 (3.4)	196 (3.5)
Clinical characteristics
Schizophrenia subtype				0.134
Paranoid	5234 (52.3)	2289 (52.4)	2945 (52.3)
Disorganized	1876 (18.8)	834 (19.1)	1042 (18.5)
Catatonic	234 (2.3)	95 (2.2)	139 (2.5)
Undifferentiated	1543 (15.4)	678 (15.5)	865 (15.4)
Schizoaffective	1113 (11.1)	474 (10.8)	639 (11.4)
Duration of illness, years	12.8 ± 9.4	14.2 ± 9.8	11.7 ± 8.9	< 0.001
Hospitalizations at our facility	4.3 ± 3.8	4.9 ± 4.2	3.8 ± 3.4	< 0.001
PANSS total score	78.4 ± 18.2	76.2 ± 17.4	80.1 ± 18.7	< 0.001
GAF score	48.3 ± 12.1	46.9 ± 11.8	49.4 ± 12.2	< 0.001

PANSS: Positive and Negative Syndrome Scale; GAF: Global Assessment of Functioning.

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Citation: Long JF, Deng LM, Zhang JD, Tang ZJ, Zhou K. Risk characteristics of obesity and atherosclerotic cardiovascular events in patients with schizophrenia: A single-center 10-year retrospective cohort study. World J Psychiatry 2026; 16(4): 114138
URL: https://www.wjgnet.com/2220-3206/full/v16/i4/114138.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i4.114138

Long JF, Deng LM, Zhang JD, Tang ZJ, Zhou K. Risk characteristics of obesity and atherosclerotic cardiovascular events in patients with schizophrenia: A single-center 10-year retrospective cohort study. World J Psychiatry 2026; 16(4): 114138 [DOI: 10.5498/wjp.v16.i4.114138]

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