Pediococcus acidilactici CCFM6432 alleviates anhedonia in major depression through immune-inflammatory modulation: An extended trial analysis

doi:10.5498/wjp.v16.i3.114446

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Randomized Controlled Trial

©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.

World J Psychiatry. Mar 19, 2026; 16(3): 114446
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.114446

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Figure 1 Comparison of concentration changes in blood biomarker levels between the two groups. This figure summarizes concentration changes in blood biomarker levels between the two groups. ^bP < 0.05 indicates a significant between-group difference (independent-samples t-test). Concentration change = baseline value - follow-up value. BDNF: Brain-derived neurotrophic factor; Pro-BDNF: Pro-brain-derived neurotrophic factor; TrkB: Tropomyosin-related kinase B; DA: Dopamine; Trp: Tryptophan; IL-1β: Interleukin-1 beta; TNF-α: Tumor necrosis factor-alpha; TLR-4: Toll-like receptor 4; NF-κB: Nuclear factor kappa B; NOD-2: Nucleotide-binding oligomerization domain-containing protein 2; LPS: Lipopolysaccharide; CRP: C-reactive protein; IL-6: Interleukin-6.

Citation: Li DX, Gu Y, Xia WJ, Sun YF, Hou L, Zhu WX, Wang J. Pediococcus acidilactici CCFM6432 alleviates anhedonia in major depression through immune-inflammatory modulation: An extended trial analysis. World J Psychiatry 2026; 16(3): 114446
URL: https://www.wjgnet.com/2220-3206/full/v16/i3/114446.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i3.114446

Li DX, Gu Y, Xia WJ, Sun YF, Hou L, Zhu WX, Wang J. Pediococcus acidilactici CCFM6432 alleviates anhedonia in major depression through immune-inflammatory modulation: An extended trial analysis. World J Psychiatry 2026; 16(3): 114446 [DOI: 10.5498/wjp.v16.i3.114446]

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