Efficacy of hyperbaric oxygen therapy in the treatment of depression

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World Journal of Psychiatry

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2220-3206

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World J Psychiatry. Mar 19, 2026; 16(3): 113572
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.113572

Table 5 GRADE assessment of the selected trials

Study design	Number of studies	Common finding	Bias risk	Variability	Indirect evidence	Precision	Other factors	Certainty
RCT	6	HBOT improves depression, cognitive function, and functional outcomes	Low to moderate	Low	Low	Moderate	None	Moderate

RCT: Randomized controlled trials; HBOT: Hyperbaric oxygen therapy.

Citation: Ahsan M, Ahmed S, Shaik RA, Ahmad MS, Nurani KM, A P. Efficacy of hyperbaric oxygen therapy in the treatment of depression. World J Psychiatry 2026; 16(3): 113572
URL: https://www.wjgnet.com/2220-3206/full/v16/i3/113572.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i3.113572

Ahsan M, Ahmed S, Shaik RA, Ahmad MS, Nurani KM, A P. Efficacy of hyperbaric oxygen therapy in the treatment of depression. World J Psychiatry 2026; 16(3): 113572 [DOI: 10.5498/wjp.v16.i3.113572]

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