Efficacy of hyperbaric oxygen therapy in the treatment of depression

doi:10.5498/wjp.v16.i3.113572

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Mar 19, 2026; 16(3): 113572
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.113572

Table 4 Vote-count summary of hyperbaric oxygen therapy efficacy across outcome domains (n = 6 randomized controlled trials)

Domain	Significant benefit (HBOT > control)	No significant difference	Significant harm
Mood/depression scales	5	1	0
Cognition/neuropsychology tests	3	1¹	0
Functional/QoL indices	4	0	0
Perfusion/imaging metrics	1	0	0

¹Two trials did not administer cognitive tests, so denominator = 4.

“Significant benefit”: At least one primary outcome in that domain showed P < 0.05 favouring hyperbaric oxygen therapy (studies could contribute to more than one domain). Numbers add up to > 6 because individual papers reported multiple endpoints. HBOT: Hyperbaric oxygen therapy.

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Citation: Ahsan M, Ahmed S, Shaik RA, Ahmad MS, Nurani KM, A P. Efficacy of hyperbaric oxygen therapy in the treatment of depression. World J Psychiatry 2026; 16(3): 113572
URL: https://www.wjgnet.com/2220-3206/full/v16/i3/113572.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i3.113572

Ahsan M, Ahmed S, Shaik RA, Ahmad MS, Nurani KM, A P. Efficacy of hyperbaric oxygen therapy in the treatment of depression. World J Psychiatry 2026; 16(3): 113572 [DOI: 10.5498/wjp.v16.i3.113572]

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