©Author(s) (or their employer(s)) 2026.
World J Psychiatry. Mar 19, 2026; 16(3): 111523
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.111523
Published online Mar 19, 2026. doi: 10.5498/wjp.v16.i3.111523
Table 2 Linear regression analysis of factors associated with higher Depression Anxiety Stress Scale 21 stress scores in patients with Crohn’s disease
| Stress | Univariate | Multivariate | ||
| β (95%CI) | P value | β (95%CI) | P value | |
| Female | 4.5 (1.5 to 7.5) | 0.003 | -8.7 (-20.5 to 3.2) | 0.145 |
| HBI | 1.2 (0.1 to 2.2) | 0.03 | 1.7 (-1.5 to 4.9) | 0.281 |
| HGB | -1.6 (-3 to -0.2) | 0.022 | -4.1 (-7.6 to -0.6) | 0.023 |
| Smoking | 6.9 (2.5 to 11.3) | 0.003 | 9.5 (3.1 to 18.4) | 0.008 |
| A Montreal1 | ||||
| A1 | Reference | |||
| A2 | 4.0 (-2.0 to 9.9) | 0.239 | -3.7 (-15.9 to 8.6) | 0.541 |
| A3 | 7.7 (1.2 to 14.2) | 0.014 | 8.5 (-4.2 to 21.3) | 0.181 |
- Citation: Laoudi E, Papalouka D, Kokkotis G, Gkizis M, Mantzou A, Lyrakos G, Markopoulos P, Prapa P, Voulgaris T, Vlachogiannakos J, Papaconstantinou I, Bamias G. Hypothalamic-pituitary-adrenal dysregulation and psychological distress in Crohn’s disease: Insights from acute and chronic stress responses. World J Psychiatry 2026; 16(3): 111523
- URL: https://www.wjgnet.com/2220-3206/full/v16/i3/111523.htm
- DOI: https://dx.doi.org/10.5498/wjp.v16.i3.111523