Aberrant topology of the default mode network is associated with phosphatidylcholine and triglyceride levels in major depressive disorder

Figure 3 Volcano plot of lipid metabolite differences between the major depressive disorder and healthy control groups. Metabolites identified via lipidomics were subjected to multivariate analysis to assess inter-group differences. Statistical significance was determined based on a combination of a variable importance in projection score > 1.0 and a false discovery rate corrected q value < 0.05. The X-axis represents log2 (fold change), and the Y-axis shows -log10 (false discovery rate q value). A total of 2033 metabolites were not significantly altered; no metabolites were up-regulated and 7 metabolites were down-regulated in the major depressive disorder group compared to healthy controls. FDR: False discovery rate; VIP: Variable importance in projection.