L-shaped association between fasting blood glucose and comorbid anxiety in Chinese patients with first-episode untreated major depressive disorder

doi:10.5498/wjp.v16.i2.113063

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Feb 19, 2026; 16(2): 113063
Published online Feb 19, 2026. doi: 10.5498/wjp.v16.i2.113063

Table 4 Two-piecewise logistic regression model results

Inflection point of FBG	Effect size (OR)	95%CI	P value
< 4.8 (mmol/L)	0.20	0.06-0.67	0.009
≥ 4.8 (mmol/L)	1.22	0.91-1.63	0.188
Log likelihood ratio test			0.005

Effect: Comorbid anxiety; Cause: Fasting blood glucose (mmol/L); Adjusted for gender, age, education, Hamilton Rating Scale for Depression, total cholesterol, triglyceride, thyroid-stimulating hormone, thyroglobulin antibody, thyroid peroxidase antibody, low-density lipoprotein cholesterol, diastolic and systolic blood pressures, suicide attempts and psychotic symptoms. FBG: Fasting blood glucose.

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Citation: Yuan L, Liu JJ, Li Z, Zhu YZ, Ren W, Liu YZ, Zhao XL, Du XD, Zhang XY. L-shaped association between fasting blood glucose and comorbid anxiety in Chinese patients with first-episode untreated major depressive disorder. World J Psychiatry 2026; 16(2): 113063
URL: https://www.wjgnet.com/2220-3206/full/v16/i2/113063.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i2.113063

Yuan L, Liu JJ, Li Z, Zhu YZ, Ren W, Liu YZ, Zhao XL, Du XD, Zhang XY. L-shaped association between fasting blood glucose and comorbid anxiety in Chinese patients with first-episode untreated major depressive disorder. World J Psychiatry 2026; 16(2): 113063 [PMID: 41641192 DOI: 10.5498/wjp.v16.i2.113063]

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