L-shaped association between fasting blood glucose and comorbid anxiety in Chinese patients with first-episode untreated major depressive disorder

Table 3 Relationship of fasting blood glucose with comorbid anxiety in different models

Variable	Crude Model		Model I		Model II		Model III		Model IV
	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
FBG	1.43 (1.18, 1.73)	< 0.001	1.43 (1.18, 1.73)	< 0.001	1.25 (1.01, 1.53)	0.038	0.93 (0.74, 1.16)	0.497	0.98 (0.77, 1.24)	0.853
FBG (tertile)
T1	0.94 (0.71, 1.24)	0.659	0.94 (0.71, 1.24)	0.670	0.95 (0.71, 1.26)	0.699	1.23 (0.91, 1.69)	0.187	1.16 (0.84, 1.60)	0.361
T2	Reference		Reference		Reference		Reference		Reference
T3	1.68 (1.24, 2.28)	< 0.001	1.69 (1.24, 2.29)	< 0.001	1.41 (1.03, 1.94)	0.034	1.16 (0.83, 1.64)	0.381	1.19 (0.84, 1.68)	0.338
P for trend	< 0.001		< 0.001		0.045		0.327		0.987

The Crude Model: Unadjusted; Model I adjusted for demographic variables (gender, age and education); Model II additionally adjusted for disease-related variables (suicide attempts, psychotic symptoms, 17-item Hamilton Rating Scale for Depression); Model III further adjusted for metabolic indicators (total cholesterol, triglyceride, low-density lipoprotein cholesterol, diastolic and systolic blood pressures); Model IV further adjusted for thyroid function indicators (thyroid-stimulating hormone, Thyroglobulin antibody, Thyroid peroxidase antibody). FBG: Fasting blood glucose.