Acupuncture on 5-hydroxytryptamine levels and clinical outcomes in depression: A systematic review and meta-analysis of randomized controlled trials

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Systematic Reviews

World J Psychiatry. Feb 19, 2026; 16(2): 113049
Published online Feb 19, 2026. doi: 10.5498/wjp.v16.i2.113049

Table 2 Egger’s test for publication bias

Outcome	Egger’s test P value	Publication bias
HAM-D	0.0424	Possible
HAM-D (antidepressants vs acupuncture + antidepressants)	0.6546	No
SDS	0.5065	No
SERS	0.8065	No

HAM-D: Hamilton Depression Rating Scale; SERS: Self-Rating Scale for the Side Effects; SDS: Self-Rating Depression Scale.

Citation: Wang Y, Wu PT, Penpat I, Zeng FC, Lu Q, Hu ZH. Acupuncture on 5-hydroxytryptamine levels and clinical outcomes in depression: A systematic review and meta-analysis of randomized controlled trials. World J Psychiatry 2026; 16(2): 113049
URL: https://www.wjgnet.com/2220-3206/full/v16/i2/113049.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i2.113049

Wang Y, Wu PT, Penpat I, Zeng FC, Lu Q, Hu ZH. Acupuncture on 5-hydroxytryptamine levels and clinical outcomes in depression: A systematic review and meta-analysis of randomized controlled trials. World J Psychiatry 2026; 16(2): 113049 [PMID: 41641205 DOI: 10.5498/wjp.v16.i2.113049]

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