Research trends of ferroptosis and pyroptosis in depression: A bibliometric analysis

Table 5 Top 10 co-cited references associated with ferroptosis and pyroptosis in depression

Type	Rank	Reference	Citations	Title	DOI	Source
Ferroptosis in depression	1	Dixon SJ (2012)	61	Ferroptosis: An iron-dependent form of nonapoptotic cell death	10.1016/j.cell.2012.03.042	Cell
	2	Jiao H (2021)	34	Traditional Chinese formula Xiaoyaosan alleviates depressive-like behavior in CUMS mice by regulating PEBP1-GPX4-mediated ferroptosis in the hippocampus	10.2147/NDT.S302443	Neuropsychiatric Disease and Treatment
	3	Dang R (2022)	34	Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1/Nrf2/HO-1/Gpx4 pathway	10.1186/s12974-022-02400-6	Journal of Neuroinflammation
	4	Stockwell BR (2017)	26	Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease	10.1016/j.cell.2017.09.021	Cell
	5	Cao H (2021)	25	Hippocampal proteomic analysis reveals activation of necroptosis and ferroptosis in a mouse model of chronic unpredictable mild stress-induced depression	10.1016/j.bbr.2021.113261	Behavioural Brain Research
	6	Jiang X (2021)	23	Ferroptosis: Mechanisms, biology and role in disease	10.1038/s41580-020-00324-8	Nature Reviews Molecular Cell Biology
	7	Wang X (2023)	22	Saikosaponin B2 ameliorates depression-induced microglia activation by inhibiting ferroptosis-mediated neuroinflammation and ER stress	10.1016/j.jep.2023.116729	Journal of Ethnopharmacology
	8	Wang Y (2021)	17	Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis	10.1016/j.lfs.2021.119551	Life Sciences
	9	Wang L (2023)	17	Targeting the ferroptosis crosstalk: Novel alternative strategies for the treatment of major depressive disorder	10.1136/gpsych-2023-101072	General Psychiatry
	10	Doll S (2019)	16	FSP1 is a glutathione-independent ferroptosis suppressor	10.1038/s41586-019-1707-0	Nature
Pyroptosis in depression	1	Alcocer-Gómez E (2014)	189	NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder	10.1016/j.bbi.2013.10.017	Brain, Behavior, and Immunity
	2	Pan Y (2014)	166	Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats	10.1016/j.bbi.2014.04.007	Brain, Behavior, and Immunity
	3	Kaufmann FN (2017)	130	NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings	10.1016/j.bbi.2017.03.002	Brain, Behavior, and Immunity
	4	Miller AH (2016)	102	The role of inflammation in depression: From evolutionary imperative to modern treatment target	10.1038/nri.2015.5	Nature Reviews Immunology
	5	Iwata M (2013)	99	The inflammasome: Pathways linking psychological stress, depression, and systemic illnesses	10.1016/j.bbi.2012.12.008	Brain, Behavior, and Immunity
	6	Zhang Y (2015)	98	NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation	10.1093/ijnp/pyv006	International Journal of Neuropsychopharmacology
	7	Zhang Y (2014)	95	Involvement of inflammasome activation in lipopolysaccharide‐induced mice depressive‐like behaviors	10.1111/cns.12170	CNS Neuroscience & Therapeutics
	8	Iwata M (2016)	92	Psychological stress activates the inflammasome via release of adenosine triphosphate and stimulation of the purinergic type 2X7 receptor	10.1016/j.biopsych.2015.11.026	Biological Psychiatry
	9	Xu Y (2016)	82	NLRP3 inflammasome activation mediates estrogen deficiency-induced depression-and anxiety-like behavior and hippocampal inflammation in mice	10.1016/j.bbi.2016.02.022	Brain, Behavior, and Immunity
	10	Yue N (2017)	79	Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors	10.1186/s12974-017-0865-y	Journal of Neuroinflammation

CUMS: Chronic unpredictable mild stress; DOI: Digital object identifier; ER: Endoplasmic reticulum; FSP1: Ferroptosis suppressor protein 1; GPX4: Glutathione peroxidase 4; HO-1: Heme oxygenase-1; NLRP3: NOD-like receptor family pyrin domain-containing 3; Nrf2: Nuclear factor erythroid 2-related factor 2; PEBP1: Phosphatidylethanolamine-binding protein 1; P2X7: P2X purinoceptor 7; Sirt1: Sirtuin 1.