Association between systemic immune-inflammation index and symptoms of depression and anxiety in patients with type 2 diabetes mellitus

Table 5 Multivariable logistic regression analysis of the systemic immune-inflammation index and comorbid depressive and anxiety symptoms

Variables		Model 1		Model 2		Model 3		Model 4
		OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
SII	Q1	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
	Q2	3.03 (1.88–4.89)	< 0.001	3.04 (1.87–4.94)	< 0.001	3.02 (1.85–4.93)	< 0.001	3.03 (1.82–5.05)	< 0.001
	Q3	6.15 (3.78–10.01)	< 0.001	5.86 (3.57–9.61)	< 0.001	5.67 (3.43–9.36)	< 0.001	5.41 (3.21–9.11)	< 0.001

Model 1: Crude model; Model 2: Adjusted for sex, smoking, drinking, age, diabetes duration, and body mass index; Model 3: Adjusted for sex, smoking, drinking, age, diabetes duration, body mass index, hypertension, coronary artery disease, stroke, chronic kidney disease, and metabolic dysfunction-associated steatotic liver disease; Model 4: Adjusted for sex, smoking, drinking, age, diabetes duration, body mass index, hypertension, coronary artery disease, stroke, chronic kidney disease, metabolic dysfunction-associated steatotic liver disease, glycated hemoglobin, fasting blood glucose, total cholesterol, triglycerides, low-density lipoprotein, high-density lipoprotein, serum creatinine, uric acid, and blood urea nitrogen. CI: Confidence interval; OR: Odds ratio; SII: Systemic immune-inflammation index.