Association between systemic immune-inflammation index and symptoms of depression and anxiety in patients with type 2 diabetes mellitus

Table 3 Multivariable logistic regression analysis of the systemic immune-inflammation index and depressive and anxiety symptoms

Variables		Model 1		Model 2		Model 3		Model 4
		OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
Depression	Q1	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
	Q2	2.13 (1.29–3.50)	0.003	2.19 (1.32–3.62)	0.002	2.13 (1.27–3.55)	0.004	2.02 (1.16–3.54)	0.014
	Q3	4.33 (2.60–7.23)	< 0.001	4.25 (2.52–7.17)	< 0.001	4.09 (2.39–6.97)	< 0.001	3.93 (2.18–7.08)	< 0.001
Anxiety	Q1	1.00 (reference)		1.00 (reference)		1.00 (reference)		1.00 (reference)
	Q2	6.12 (2.84–13.22)	< 0.001	6.22 (2.84–13.61)	< 0.001	6.16 (2.80–13.55)	< 0.001	6.30 (2.83–14.04)	< 0.001
	Q3	9.97 (4.67–21.29)	< 0.001	9.20 (4.24–19.93)	< 0.001	9.15 (4.19–19.98)	< 0.001	9.21 (4.16–20.39)	< 0.001

Model 1: Crude model; Model 2: Adjusted for sex, smoking, drinking, age, diabetes duration, and body mass index; Model 3: Adjusted for sex, smoking, drinking, age, diabetes duration, body mass index, hypertension, coronary artery disease, stroke, chronic kidney disease, and metabolic dysfunction-associated steatotic liver disease; Model 4: Adjusted for sex, smoking, drinking, age, diabetes duration, body mass index, hypertension, coronary artery disease, stroke, chronic kidney disease, metabolic dysfunction-associated steatotic liver disease, glycated hemoglobin, fasting blood glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, serum creatinine, uric acid, and blood urea nitrogen. CI: Confidence interval; OR: Odds ratio.