Systemic immune-inflammation index and postoperative anxiety after transforaminal endoscopic lumbar discectomy

Table 2 Comparison of inflammatory and immune markers between anxiety and non-anxiety groups

Variable	Anxiety group (n = 47)	Non-anxiety group (n = 133)	P value
Preoperative SII	412.5 ± 168.3	389.6 ± 152.7	0.396
Postoperative SII	587.4 ± 198.6	423.8 ± 156.3	< 0.001
Preoperative TNF-α (pg/mL)	15.4 ± 6.2	14.1 ± 5.8	0.208
Postoperative TNF-α (pg/mL)	28.6 ± 9.4	21.3 ± 7.8	< 0.001
Preoperative IL-6 (pg/mL)	8.6 ± 4.3	7.9 ± 3.8	0.307
Postoperative IL-6 (pg/mL)	45.8 ± 18.7	29.4 ± 12.6	< 0.001
Preoperative CRP (mg/L)	4.8 ± 3.2	4.2 ± 2.9	0.248
Postoperative CRP (mg/L)	32.4 ± 14.5	19.8 ± 10.3	< 0.001
Preoperative PCT (ng/mL)	0.05 ± 0.03	0.04 ± 0.02	0.312
Postoperative PCT (ng/mL)	0.18 ± 0.09	0.11 ± 0.06	< 0.001
Preoperative RF (IU/mL)	16.8 ± 8.4	13.5 ± 6.9	0.032
Postoperative RF (IU/mL)	17.2 ± 8.1	14.8 ± 7.3	0.058
ANA positive, n (%)	8 (17.0)	16 (12.0)	0.287
Preoperative IgG (g/L)	12.4 ± 2.8	12.8 ± 3.1	0.438
Postoperative IgG (g/L)	11.6 ± 2.5	12.3 ± 2.9	0.068
Preoperative IgA (g/L)	2.3 ± 0.8	2.2 ± 0.7	0.446
Postoperative IgA (g/L)	2.1 ± 0.7	2.2 ± 0.8	0.618
Preoperative IgM (g/L)	1.2 ± 0.4	1.1 ± 0.5	0.226
Postoperative IgM (g/L)	1.1 ± 0.4	1.1 ± 0.4	0.854

SII: Systemic immune-inflammation index; TNF-α: Tumor necrosis factor alpha; IL-6: Interleukin-6; PCT: Procalcitonin; CRP: C-reactive protein; RF: Rheumatoid factor; IgG: Immunoglobulin G; IgA: Immunoglobulin A; IgM: Immunoglobulin M.