Development and validation of a nomogram model for identifying post-stroke anxiety symptoms

Table 3 Differences between patients with anxiety and those without anxiety within the training set, n (%)

Variables	No anxiety (n = 563)	Anxiety (n = 99)	Z/χ2	P value
NIHSS score	2.00 (1.00, 4.00)	2.00 (1.00, 4.25)	-0.63	0.53
mRS score	2.00 (1.00, 3.00)	2.00 (2.00, 3.00)	-0.69	0.493
Hcy	13.80 (10.70, 17.72)	14.05 (11.25, 18.20)	-0.53	0.597
TSH	2.00 (1.19, 3.07)	1.82 (1.17, 3.01)	-0.66	0.508
CRP	2.70 (1.00, 7.40)	2.76 (1.00, 11.92)	-1.59	0.111
Age (years)	68.00 (59.00, 75.00)	58.50 (52.00, 66.50)	-5.95	0.01b
Type of stroke	-	-	6.60	0.01b
Ischemic stroke	505 (90.50)	102 (98.08)	-	-
Hemorrhagic stroke	53 (9.50)	2 (1.92)	-	-
TOAST classification	-	-	3.19	0.364
Stroke of undetermined etiology	11 (2.19)	2 (1.96)	-	-
Large vessel atherosclerosis	342 (67.99)	75 (73.53)	-	-
Small vessel occlusion	119 (23.66)	23 (22.55)	-	-
Cardio-embolic source	31 (6.16)	2 (1.96)	-	-
Time since stroke	-	-	6.68	0.035a
> 6 months	6 (1.08)	3 (2.88)	-	-
> 7 days ≤ 6 months	331 (59.32)	49 (47.12)	-	-
≤ 7 days	221 (39.61)	52 (50.00)	-	-
Sex	-	-	0.01	0.938
Male	351 (62.90)	65 (62.50)	-	-
Female	207 (37.10)	39 (37.50)	-	-
Employment status	-	-	16.59	0.01b
Employed	72 (12.90)	29 (27.88)	-	-
Retired	172 (30.82)	21 (20.19)	-	-
Unemployed	314 (56.27)	54 (51.92)	-	-
Educational attainment	-	-	1.79	0.409
Junior high school and below	459 (82.26)	79 (76.70)	-	-
College or university	30 (5.38)	7 (6.80)	-	-
High school or technical secondary school	69 (12.37)	17 (16.50)	-	-
Feeling pain after stroke	-	-	23.86	0.01b
Yes	33 (5.91)	21 (20.19)	-	-
No	525 (94.09)	83 (79.81)	-	-
Pre-stroke sleep duration	-	-	12.45	0.006b
< 5 hours	101 (18.10)	30 (28.85)	-	-
5-6 hours	77 (13.80)	17 (16.35)	-	-
6-7 hours	35 (6.27)	11 (10.58)	-	-
> 7 hours	345 (61.83)	46 (44.23)	-	-
History of hyperlipidemia	-	-	9.44	0.002b
No	492 (88.17)	80 (76.92)	-	-
Yes	66 (11.83)	24 (23.08)	-	-
History of migraine	-	-	8.37	0.004b
No	552 (98.92)	98 (94.23)	-	-
Yes	6 (1.08)	6 (5.77)	-	-
Family history of stroke	-	-	21.16	0.01b
No	547 (98.03)	92 (88.46)	-	-
Yes	11 (1.97)	12 (11.54)	-	-
Depression	-	-	102.79	0.01b
No	507 (90.86)	54 (51.92)	-	-
Yes	51 (9.14)	50 (48.08)	-	-

^aP < 0.05.

^bP < 0.01.

NIHSS: Neurological Institute of Health Stroke Scale; mRS: Modified Rankin Scale; Hcy: Homocysteine; TSH: Thyroid-stimulating hormone; CRP: C-reactive protein; TOAST: Trial of ORG 10172 in Acute Stroke Treatment.