Do serum biomarker levels correlate with anxiety disorders?

Table 2 Diagnostic value of serum brain-derived neurotrophic factor, mature brain-derived neurotrophic factor, brain-derived neurotrophic factor precursor, aquaporin-4, and glycogen synthase kinase-3β levels in anxiety disorder

Group	AUC	95%CI	Sensitivity	Specificity	Cut-off value	P value
BDNF	0.8200	0.7189-0.9210	0.8065	0.6452	15.26	< 0.05
mBDNF	0.7211	0.5891-0.8532	0.5484	0.9032	776.20	< 0.05
proBDNF	0.7430	0.6106-0.8754	0.9677	0.5806	938.30	< 0.05
AQP4	0.7170	0.5877--0.8462	1.0000	0.4194	32.84	< 0.05
GSK3β	0.6452	0.5011-0.7892	0.4839	0.9355	640.10	< 0.05
Combined diagnosis	0.9698	0.9360-1.000	1.0000	1.0000	/	< 0.05

Optimal cut-off values were determined by the maximum Youden index (sensitivity + specificity - 1) based on raw serum concentrations. The combined diagnosis was constructed using multiple logistic regression. AQP4: Aquaporin-4; GSK3β: Glycogen synthase kinase-3β; BDNF: Brain-derived neurotrophic factor; mBDNF: Mature brain-derived neurotrophic factor; proBDNF: Brain-derived neurotrophic factor precursor.