Impact of post-stroke depression on the prognosis of stroke-associated pneumonia and analysis of predictive factors: A retrospective study of 186 patients

Table 4 Laboratory biomarkers in depression and non-depression groups (day 7), mean ± SD

Biomarker	Depression group (n = 92)	Non-depression group (n = 94)	P value
Infection markers
PCT (ng/mL)	2.85 ± 1.32	1.52 ± 0.85	< 0.001
CRP (mg/L)	85.6 ± 28.5	52.3 ± 18.6	< 0.001
WBC (× 109/L)	13.8 ± 4.2	11.2 ± 3.5	0.001
Inflammatory cytokines
IL-6 (pg/mL)	42.5 ± 12.8	25.8 ± 8.5	< 0.001
TNF-α (pg/mL)	28.5 ± 8.2	18.2 ± 5.8	< 0.001
IL-10 (pg/mL)	8.5 ± 2.8	12.2 ± 3.5	< 0.001
Neurotrophic factor
BDNF (ng/mL)	11.8 ± 4.2	21.5 ± 6.8	< 0.001
Neuroendocrine
Morning cortisol (nmol/L)	408.5 ± 105.2	325.8 ± 78.5	< 0.001
Immune function
Lymphocyte (× 109/L)	0.95 ± 0.32	1.35 ± 0.42	< 0.001
CD4+ T cells (cells/μL)	285 ± 78	425 ± 95	< 0.001
CD4/CD8 ratio	1.05 ± 0.35	1.52 ± 0.42	< 0.001
Nutritional markers
Albumin (g/L)	28.5 ± 4.8	34.2 ± 5.2	< 0.001
Prealbumin (mg/L)	125 ± 35	185 ± 42	< 0.001
Transferrin (g/L)	1.52 ± 0.38	1.95 ± 0.45	< 0.001
Metabolic
HbA1c (%)	7.2 ± 1.5	6.5 ± 1.2	0.028
Fasting glucose (mmol/L)	8.5 ± 2.2	7.2 ± 1.8	0.012

PCT: Procalcitonin; CRP: C-reactive protein; WBC: White blood cell; IL-6: Interleukin-6; TNF-α: Tumor necrosis factor-alpha; IL-10: Interleukin-10; BDNF: Brain-derived neurotrophic factor; HbA1c: Glycated hemoglobin.