Glycemic indicators influence hypercoagulability via multisystem pathways in psychiatric inpatients: Structural equation modeling

Figure 1 Multisystem pathway model linking three glycemic indicators to D-dimer hypercoagulability in psychiatric inpatients. Three mutually adjusted glycemic indicators (fasting plasma glucose, fructosamine, and glycated hemoglobin) were modeled as competing exposures influencing four upstream multi-system pathways composites (lipid, blood pressure, inflammation, and nutrition), which in turn acted through two proximal coagulation mediators-Coag (Substrate) and Coag (Time)-to affect hypercoagulable status (D-dimer > 0.5 μg/mL). BP: Blood pressure; FA: Fructosamine; FPG: Fasting plasma glucose; HbA1c: Glycated hemoglobin.