Glycemic indicators influence hypercoagulability via multisystem pathways in psychiatric inpatients: Structural equation modeling

Table 7 Model fit indices for the main structural equation modeling and sensitivity analyses¹

Model	NPAR	df	CFI	TLI	RMSEA	SRMR	RMSEA (CI)	NOBS
Main model	119	6	0.990	0.966	0.041	0.001	0.041 (0.030-0.053)	3783
SCZ subgroup model	119	6	0.988	0.960	0.037	0.001	0.037 (0.019-0.057)	1511
BD subgroup model	119	6	0.983	0.941	0.049	0.004	0.049 (0.025-0.075)	876
MDD subgroup model	119	6	0.989	0.962	0.053	0.003	0.053 (0.035-0.073)	1396
Sensitivity model
Sensitivity partial mediation (direct-coag) model	125	0	1	1	0	0	0.000 (0.000-0.000)	3783
Sensitivity full mediation model	112	13	0.958	0.933	0.057	0.026	0.057 (0.050-0.065)	3783
Sensitivity log(D-dimer) outcome model	120	6	0.949	0.821	0.044	0.141	0.044 (0.035-0.054)	3783
Sensitivity lipid (AIP) model	119	6	0.987	0.955	0.045	0.001	0.045 (0.034-0.057)	3783
Sensitivity inflammation (Winsor) model	119	6	0.987	0.956	0.040	0.001	0.040 (0.030-0.052)	3783
Sensitivity inflammation (SIRI) model	119	6	0.973	0.907	0.049	0.002	0.049 (0.039-0.060)	4284
Sensitivity inflammation (extended) model	119	6	0.986	0.952	0.042	0.001	0.042 (0.031-0.053)	3783
Sensitivity nutrition (CONUT) model	119	6	0.991	0.969	0.038	0.001	0.038 (0.027-0.050)	3783
Sensitivity nutrition (PNI) model	119	6	0.990	0.965	0.04	0.003	0.040 (0.030-0.052)	3783
Sensitivity coag (substrate) model	101	3	0.993	0.966	0.042	0.001	0.042 (0.027-0.059)	3783
Sensitivity coag (time) model	101	3	0.973	0.865	0.041	0.000	0.041 (0.026-0.058)	3783
Sensitivity coag (composite) model	101	3	0.994	0.968	0.051	0.001	0.051 (0.037-0.068)	3783
Sensitivity covars (extended) model	133	6	0.990	0.964	0.042	0.001	0.042 (0.031-0.054)	3783
Sensitivity single-sugar (FPG) model	109	2	0.997	0.973	0.038	0.001	0.038 (0.020-0.059)	3783
Sensitivity single-sugar (FA) model	109	2	0.985	0.839	0.089	0.002	0.089 (0.071-0.108)	3783
Sensitivity single-sugar (FA-ALBcorr) model	109	2	0.981	0.801	0.105	0.003	0.105 (0.086-0.124)	3783
Sensitivity single-sugar (HbA1c) model	109	2	0.995	0.946	0.076	0.002	0.076 (0.058-0.096)	3783
Sensitivity tri-sugar (FA-ALBcorr) model	119	6	0.992	0.972	0.039	0.002	0.039 (0.028-0.051)	3783
Sensitivity gly-composite (FA) model	109	2	0.985	0.842	0.089	0.002	0.089 (0.070-0.108)	3783
Sensitivity gly-composite (FA-ALBcorr) model	109	2	0.984	0.832	0.094	0.002	0.094 (0.075-0.113)	3783

¹This table reports global model fit indices for the main serial SEM, diagnosis-specific subgroup models, and a set of prespecified sensitivity analyses. Sensitivity analyses were designed to assess the robustness of the main mechanistic conclusions under alternative assumptions, including structural constraints (partial vs full mediation), outcome specification (binary vs continuous D-dimer), exposure definitions (single-glycemic indicators, alternative tri-sugar configurations, and glycemic composites), mediator operationalization (lipid, inflammatory, nutritional, and coagulation domains), and covariate extension. Models with zero degrees of freedom are just-identified; therefore, their fit indices (e.g., comparative fit index = 1.00, root mean square error of approximation = 0) are mathematically determined and should not be interpreted as indicators of superior model fit. The number of observations (number of observations) varies across models due to variable-specific missingness, with each model estimated using all available data under its corresponding specification. Sensitivity analyses were not intended to identify an optimal-fitting model, but rather to evaluate the stability and consistency of model fit and structural conclusions across alternative modeling scenarios.

NPAR: Number of free parameters; CFI: Comparative fit index; TLI: Tucker-Lewis index; RMSEA: Root mean square error of approximation; SRMR: Standardized root mean square residual; CI: Confidence interval; NOBS: Number of observations; SCZ: Schizophrenia; BD: Bipolar disorder; MDD: Major depressive disorder; PNI: Prognostic nutritional index; CONUT: Controlling nutritional status; FPG: Fasting plasma glucose; FA: Fructosamine; HbA1c: Glycated hemoglobin; ALB: Albumin; AIP: Atherogenic index of plasma.