Glycemic indicators influence hypercoagulability via multisystem pathways in psychiatric inpatients: Structural equation modeling

Table 6 Stability of structural equation modeling structural pathways across diagnostic subgroups

Path	ALL Std.β (95%CI)	SCZ Std.β (95%CI)	BD Std.β (95%CI)	MDD Std.β (95%CI)
FPG → Lipid index	-0.04 (-0.09 to 0.01)	-0.06 (-0.15 to 0.02)	-0.07 (-0.20 to 0.06)	0.04 (-0.04 to 0.11)
FPG → BP index	0.11 (0.06, 0.16)	0.06 (-0.01 to 0.14)	0.08 (-0.02 to 0.19)	0.10 (0.02, 0.18)
FPG → Inflamm index	0.08 (0.02, 0.15)	0.14 (0.02, 0.26)	0.02 (-0.08 to 0.11)	-0.01 (-0.11 to 0.07)
FPG → Nutrition index	-0.04 (-0.09 to 0.00)	-0.00 (-0.09 to 0.08)	-0.02 (-0.12 to 0.08)	-0.10 (-0.19 to 0.00)
FA → Lipid index	0.23 (0.17, 0.27)	0.30 (0.24, 0.38)	0.17 (0.08, 0.26)	0.18 (0.10, 0.26)
FA → BP index	0.09 (0.05, 0.13)	0.06 (-0.01 to 0.14)	0.11 (0.03, 0.20)	0.06 (-0.00 to 0.13)
FA → Inflamm index	-0.00 (-0.06 to 0.06)	-0.04 (-0.14 to 0.08)	-0.02 (-0.11 to 0.11)	0.03 (-0.07 to 0.15)
FA → Nutrition index	-0.32 (-0.37 to -0.29)	-0.31 (-0.38 to -0.24)	-0.32 (-0.39 to -0.24)	-0.33 (-0.41 to -0.26)
HbA1c → Lipid index	0.06 (0.01, 0.12)	-0.00 (-0.10 to 0.09)	0.16 (0.03, 0.28)	0.06 (-0.03 to 0.16)
HbA1c → BP index	-0.05 (-0.11 to 0.00)	-0.03 (-0.13 to 0.06)	-0.02 (-0.12 to 0.08)	-0.01 (-0.09 to 0.08)
HbA1c → Inflamm index	0.04 (-0.01 to 0.10)	0.00 (-0.10 to 0.13)	0.11 (-0.02 to 0.24)	0.19 (0.10, 0.29)
HbA1c → Nutrition index	0.17 (0.11, 0.23)	0.18 (0.08, 0.28)	0.11 (0.00, 0.20)	0.16 (0.02, 0.26)
Lipid → Coag (substrate)	0.12 (0.08, 0.15)	0.11 (0.05, 0.16)	0.09 (0.03, 0.16)	0.14 (0.08, 0.19)
BP → Coag (substrate)	0.08 (0.05, 0.12)	0.08 (0.03, 0.13)	0.11 (0.03, 0.17)	0.05 (-0.00 to 0.09)
Inflamm → Coag (substrate)	0.42 (0.38, 0.46)	0.40 (0.35, 0.45)	0.41 (0.32, 0.51)	0.45 (0.39, 0.50)
Nutrition → Coag (substrate)	-0.01 (-0.04 to 0.02)	0.03 (-0.03 to 0.09)	-0.02 (-0.08 to 0.05)	-0.05 (-0.10 to 0.00)
Lipid → Coag (time)	0.07 (0.03, 0.11)	0.03 (-0.02 to 0.10)	0.12 (0.03, 0.20)	0.10 (0.05, 0.16)
BP → Coag (time)	0.07 (0.04, 0.11)	0.07 (0.03, 0.14)	0.04 (-0.03 to 0.11)	0.07 (0.02, 0.13)
Inflamm → Coag (time)	-0.02 (-0.06 to 0.01)	0.01 (-0.03 to 0.04)	-0.07 (-0.15 to 0.00)	-0.06 (-0.14 to 0.03)
Nutrition → Coag (time)	-0.01 (-0.07 to 0.04)	0.04 (-0.07 to 0.10)	-0.06 (-0.14 to 0.01)	-0.05 (-0.12 to 0.00)
FPG → D-dimer	0.12 (0.04, 0.18)	0.11 (-0.02 to 0.24)	0.13 (-0.03 to 0.28)	0.09 (0.00, 0.19)
FA → D-dimer	-0.19 (-0.27 to -0.13)	-0.24 (-0.38 to -0.12)	-0.17 (-0.33 to -0.02)	-0.16 (-0.28 to -0.06)
HbA1c → D-dimer	0.03 (-0.04 to 0.11)	0.03 (-0.10 to 0.17)	0.06 (-0.11 to 0.21)	0.06 (-0.05 to 0.16)
Lipid → D-dimer	0.00 (-0.05 to 0.06)	0.01 (-0.08 to 0.11)	-0.11 (-0.23 to 0.01)	0.06 (-0.03 to 0.14)
BP → D-dimer	-0.03 (-0.08 to 0.02)	-0.07 (-0.14 to 0.01)	-0.04 (-0.18 to 0.10)	-0.02 (-0.11 to 0.05)
Inflamm → D-dimer	0.16 (0.09, 0.26)	0.16 (0.06, 0.29)	0.21 (-0.02 to 0.38)	0.11 (-0.03 to 0.35)
Nutrition → D-dimer	0.08 (0.03, 0.13)	0.06 (-0.03 to 0.15)	0.16 (0.03, 0.27)	0.07 (-0.01 to 0.16)
Coag (substrate) → D-dimer	-0.09 (-0.15 to -0.03)	-0.06 (-0.15 to 0.02)	-0.12 (-0.25 to 0.02)	-0.12 (-0.26 to -0.03)
Coag (time) → D-dimer	-0.02 (-0.07 to 0.03)	-0.05 (-0.15 to 0.05)	-0.05 (-0.15 to 0.06)	0.05 (-0.02 to 0.14)

BP: Blood pressure; FPG: Fasting plasma glucose; FA: Fructosamine; HbA1c: Glycated hemoglobin.