Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study

doi:10.5498/wjp.v16.i1.113064

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Jan 19, 2026; 16(1): 113064
Published online Jan 19, 2026. doi: 10.5498/wjp.v16.i1.113064

Table 3 Brain areas with significantly different regional homogeneity values among healthy control, obesity, major depressive disorder, and comorbid major depressive disorder-obesity groups

Brain	Peak MNI Coordinates			F	Cluster size
Brain	X	Y	Z	F	Cluster size
MTG.L	-57	-39	0	24.67	59
Cuneus.R	3	-84	36	28.39	36
Precuneus.L	-6	-78	45	29.6	50
Thalamus.L	-15	-27	0	25.05	26

MTG.L: Left middle temporal gyrus; Cuneus.R: Cuneus right; Precuneus.L: Precuneus left; Thalamus.L: Thalamus left.

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Citation: Hou XF, Mei BH, Wang X, Zhao FT, He L, Chen QY, Zang C, Wang C, Tang YF, Li XX, Zhang HF, Wang N, Cao B. Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study. World J Psychiatry 2026; 16(1): 113064
URL: https://www.wjgnet.com/2220-3206/full/v16/i1/113064.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i1.113064

Hou XF, Mei BH, Wang X, Zhao FT, He L, Chen QY, Zang C, Wang C, Tang YF, Li XX, Zhang HF, Wang N, Cao B. Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study. World J Psychiatry 2026; 16(1): 113064 [PMID: 41607434 DOI: 10.5498/wjp.v16.i1.113064]

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