Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study

doi:10.5498/wjp.v16.i1.113064

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World Journal of Psychiatry

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2220-3206

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Observational Study

World J Psychiatry. Jan 19, 2026; 16(1): 113064
Published online Jan 19, 2026. doi: 10.5498/wjp.v16.i1.113064

Table 2 Demographic features of participants in the study, n (%)

Variables	HC (n = 37)	OB (n = 42)	MDD (n = 47)	MDD-OB (n = 23)	F/χ²	P value	Post-hoc analysis
Age	40.92 (8.61)	38.6 (9.21)	38.11 (12.99)	34 (11.02)	2.10	0.104
Sex (male/female)	14/23	23/19	23/24	7/16	5.02	0.171
BMI	23.24 (2.12)	30.96 (2.48)	22.36 (2.97)	33.14 (8.85)	61.01	< 0.001	OB > HC, MDD; MDD-OB > HC, OB, MDD-OB
HAMD-24	1.946 (2.95)	4.048 (6.77)	29.617 (11.33)	26.08 (14.101)	93.83	< 0.001	MDD > HC, OB; MDD-OB > HC, OB
Behavioral activation/inhibition
BASR	12.81 (1.74)	13.41 (1.68)	11.51 (2.59)	12.22 (1.91)	6.51	< 0.001	HC > MDD; OB > MDD, MDD-OB
BASD	11.39 (2.20)	17.41 (1.70)	15.51 (2.23)	15.87 (2.88)	49.52	< 0.001	OB > HC, MDD, MDD-OB; MDD > HC; MDD-OB > HC
BASF	14.28 (2.54)	20.03 (2.07)	18.33 (2.58)	19.35 (2.37)	40.32	< 0.001	OB > HC, MDD; MDD > HC; MDD-OB > HC
BIS	14.44 (2.01)	19.82 (2.42)	20.11 (3.39)	21.04 (2.23)	43.15	< 0.001	OB > HC; MDD > HC; MDD-OB > HC
Mean FD_Jenkinson¹	0.8 (0.04)	0.11 (0.07)	0.09 (0.06)	0.11 (0.06)	2.10	0.102

¹Jenkinson mean framewise displacement.

HC: Healthy control; OB: Obesity; MDD: Major depressive disorder; BMI: Body mass index; HAMD-24: Hamilton Depression Rating Scale-24; BASR: Behavioral activation system-reward responsiveness; BASD: Behavioral activation system-drive; BASF: Behavioral activation system-fun seeking; BIS: Behavioral inhibition system.

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Citation: Hou XF, Mei BH, Wang X, Zhao FT, He L, Chen QY, Zang C, Wang C, Tang YF, Li XX, Zhang HF, Wang N, Cao B. Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study. World J Psychiatry 2026; 16(1): 113064
URL: https://www.wjgnet.com/2220-3206/full/v16/i1/113064.htm
DOI: https://dx.doi.org/10.5498/wjp.v16.i1.113064

Hou XF, Mei BH, Wang X, Zhao FT, He L, Chen QY, Zang C, Wang C, Tang YF, Li XX, Zhang HF, Wang N, Cao B. Abnormal regional spontaneous brain activity in major depressive disorder with obesity comorbidity: A resting-state functional magnetic resonance imaging study. World J Psychiatry 2026; 16(1): 113064 [PMID: 41607434 DOI: 10.5498/wjp.v16.i1.113064]

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