Protective effect of Guanxinning on antipsychotic-induced cardiac impairment in long-term hospitalized psychiatric patients

Table 6 Comparison of left ventricular ejection fraction, corrected QT, and B-type natriuretic peptideindicators before and after treatment between the intervention group and the control group

Indicators	Groups	Baseline	12 months	Time effect	Group effect	Interaction effect
LVEF (%)	Guanxinning intervention group	53.5 ± 4.9	58.5 ± 5.2	F = 45.3	F = 38.6	F = 32.1
	Control group	53.2 ± 4.8	53.8 ± 4.9	P < 0.001	P < 0.001	P < 0.001
QTc interval (millisecond)	Guanxinning intervention group	462 ± 28	438 ± 25	F = 39.7	F = 42.8	F = 35.9
	Control group	465 ± 30	462 ± 28	P < 0.001	P < 0.001	P < 0.001
BNP (pg/mL), median (interquartile range)	Guanxinning intervention group	68 (45-95)	52 (35-75)	-	-	-
	Control group	72 (48-98)	78 (55-105)	-	-	-

LVEF: Left ventricular ejection fraction; QTc: Corrected QT; BNP: B-type natriuretic peptide.