Effects of celecoxib combined with duloxetine on chronic pain, depression, and anxiety in patients with knee osteoarthritis

Table 3 Hepatorenal function comparisons

Group	ALT (U/L)		AST (U/L)		Cr (μmol/L)		BUN (mmol/L)
	Pre-treatment	Post-treatment	Pre-treatment	Post-treatment	Pre-treatment	Post-treatment	Pre-treatment	Post-treatment
Control group (n = 57)	23.11 ± 10.18	24.74 ± 6.45	23.83 ± 6.79	26.08 ± 6.64	62.44 ± 17.62	62.49 ± 14.46	4.06 ± 1.15	4.34 ± 1.83
Study group (n = 66)	23.45 ± 7.88	26.76 ± 9.17	23.48 ± 5.11	25.57 ± 7.35	57.28 ± 16.39	62.16 ± 14.82	3.88 ± 1.83	4.30 ± 1.24
t value	-0.208	-1.393	0.321	0.403	1.681	0.127	0.631	0.155
P value	0.836	0.167	0.748	0.688	0.095	0.899	0.529	0.877

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; Cr: Creatinine; BUN: Blood urea nitrogen.