Modulating nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 in liver-brain axis disorders

Table 6 Natural monomers modulating the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway to mitigate hepatocellular carcinoma

Monomers	Disease models	Mechanisms	Role	Ref.
Curcumin	HCC	Reduces oxidative damage and inflammation	Improve	Khalil et al[178]
Resveratrol	HCC	Against oxidative stress	Improve	Amirshahrokhi and Niapour[179]
Berberine	HCC	Reduces hepatic triglyceride accumulation and oxidative stress	Improve	Bellaver et al[181]
Tanshinone IIA	HCC	Reduces oxidative stress markers and enhances antioxidant defenses	Improve	Zhao et al[182]
Ginsenosides	HCC	Inhibits inflammasomes	Improve	Gao et al[183]
Brusatol	HCC	Mediates ferroptosis	Improve	Görg et al[184]
Oleanolic acid oxime derivatives	HCC	Reduces cell cycle, apoptosis, and proliferation	Improve	Navarro and Esteras[185]
Emodin	HCC	Suppresses cell proliferation, invasion, and angiogenesis	Improve	Wang et al[186]

HCC: Hepatocellular carcinoma.