Modulating nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 in liver-brain axis disorders

Table 5 Natural monomers modulating the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway to mitigate liver fibrosis and cirrhosis

Monomers	Disease models	Mechanisms	Role	Ref.
Curcumin	Cirrhosis	Reduces collagen I deposition	Improve	Yatoo et al[162]
Curcumin	Fibrosis	Reduces oxidative stress, inflammatory and fibrotic markers	Improve	Sailo et al[163]
Pomegranate extract	Fibrosis	Reduces oxidative stress, inflammatory and fibrotic markers	Improve	Sailo et al[163]
Hyperoside	Fibrosis	Reduces oxidative stress, restores antioxidant enzyme activities	Improve	Manawy et al[164]
Schisandrin B	Fibrosis	Mitigates oxidative stress, suppresses HSC activation	Improve	Robledinos-Antón et al[165]
Tanshinol	Fibrosis	Reduces oxidative stress, MDA, inflammatory	Improve	Kundrapu and Malla[166]
Salvianolic acid A	Fibrosis	Inhibits inflammation and oxidative stress	Improve	Wu et al[167]
Asiatic acid	Fibrosis	Reduces oxidative stress	Improve	Wang et al[168]

HSC: Hepatic stellate cell; MDA: Malondialdehyde.