Role of RNA-binding proteins in exercise-induced mRNA regulation: Unveiling biomarkers and therapeutic targets for schizophrenia

Table 2 RNA binding protein as biomarkers and therapeutic targets in schizophrenia

Biomarker	Mechanism of action	Therapeutic target	Ref.
FMRP	Downregulation of FMRP is associated with synaptic dysfunction, likely impacting cognitive deficits	Improve cognitive ability by restoring normal FMRP function to treat cognitive impairments	[37]
TDP-43	Excessive aggregation of TDP-43 is linked to neurodegeneration and impaired synaptic remodeling	Target TDP-43 aggregation to slow neurodegenerative changes	[82]
RBFOX1	Downregulation of RBFOX1 is associated with abnormalities in neurodevelopment and synaptic function	Use gene therapy to reinstate RBFOX1 function and improve cognitive deficits	[83]
CPEB	CPEB performs a key role in synaptic plasticity and neurodevelopment	Regulate CPEB expression through RNA interference to improve synaptic function and neuroplasticity	[84]

FMRP: Fragile X mental retardation protein; TDP-43: TAR DNA-binding protein 43; RBFOX1: RNA binding fox-1 homolog; CPEB: Cytoplasmic polyadenylation element-binding protein.