Decreased inter- and intra-network connectivity after group cognitive behavioral therapy in patients with unmedicated obsessive-compulsive disorder

doi:10.5498/wjp.v15.i8.107860

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World Journal of Psychiatry

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2220-3206

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Psychiatry. Aug 19, 2025; 15(8): 107860
Published online Aug 19, 2025. doi: 10.5498/wjp.v15.i8.107860

Table 6 Comparison of default mode network, dorsal attention network, frontoparietal network, and salience network intra- and inter-network functional connectivity before and after group cognitive-behavioral therapy

	Before-GCBT	After-GCBT	t	P value
Intra-network
DMN
dmPFC-vmPFC	0.38 ± 0.24	0.22 ± 0.23	2.37	0.022
vmPFC-LSFG	0.22 ± 0.20	0.09 ± 0.20	2.18	0.035
vmPFC-LIFG	0.33 ± 0.24	0.13 ± 0.26	2.68	0.010
Pcu-RIFG	0.23 ± 0.22	0.06 ± 0.20	2.70	0.010
LIFG-RIFG	0.62 ± 0.25	0.43 ± 0.18	3.00	0.004
DAN
LFEF-LSOG	0.50 ± 0.28	0.35 ± 0.24	2.04	0.047
LFEF-RSOG	0.37 ± 0.26	0.15 ± 0.25	3.01	0.003^a
Inter-network
DMN-DAN
vmPFC-RFEF	0.13 ± 0.22	-0.04 ± 0.16	2.99	0.004^a
vmPFC-RSOG	0.16 ± 0.22	0.04 ± 0.15	2.17	0.035
RIFG-LFEF	0.20 ± 0.26	0.04 ± 0.24	2.03	0.048
RIFG-RFEF	0.25 ± 0.27	0.10 ± 0.19	2.17	0.035
RIFG-RSOG	0.22 ± 0.21	0.08 ± 0.21	2.26	0.028
DMN-FPN
LSFG-LDLPFC	0.03 ± 0.24	-0.13 ± 0.23	2.26	0.029
RIFG-RaIPL	0.20 ± 0.26	-0.01 ± 0.26	2.62	0.012
RIFG-LDLPFC	0.24 ± 0.28	-0.00 ± 0.26	3.02	0.004
RIFG-RDLPFC	0.04 ± 0.21	-0.19 ± 0.21	3.85	0.000^b
RIFG-RDLPFC	0.04 ± 0.21	-0.19 ± 0.21	3.85	0.000^b
DMN-SAN
LSFG-dACC	0.20 ± 0.25	0.03 ± 0.21	2.47	0.017
LIFG-LaINS	0.24 ± 0.24	0.11 ± 0.19	2.11	0.040
RIFG-LaINS	0.07 ± 0.17	0.34 ± 0.28	5.13	0.000^b
RIFG-RaINS	0.34 ± 0.28	0.09 ± 0.19	3.53	0.001^a
RIFG-dACC	0.34 ± 0.29	0.09 ± 0.26	3.13	0.003^a
DAN-SAN
RFEF-RaINS	0.34 ± 0.20	0.20 ± 0.13	2.91	0.005^a
LSOG-LaINS	0.29 ± 0.23	0.12 ± 0.26	2.38	0.022
LSOG-RaINS	0.24 ± 0.20	0.11 ± 0.23	2.09	0.043

^aP < 0.05, differences were considered statistically significant, uncorrected.

^bP < 0.001, uncorrected.

DMN: Default mode network; DAN: Dorsal attention network; FPN: Frontoparietal network; SAN: Salience network; dmPFC: Dorsomedial prefrontal cortex; vmPFC: Ventral medial prefrontal cortex; PCC: Posterior cingulate cortex; Pcu: Precuneus; SFG: Superior frontal gyrus; IFG: Inferior frontal gyrus; FEF: Frontal eye field; SOG: Superior occipital gyrus; aIPL: Inferior parietal lobule; DLPFC: Dorsolateral prefrontal cortex; aINS: Anterior insula; dACC: Dorsal anterior cingulate cortex; L: Left; R: Right; GCBT: Group cognitive-behavioral therapy.

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Citation: Zhang ZF, He Y, Su YQ, Liu JM. Decreased inter- and intra-network connectivity after group cognitive behavioral therapy in patients with unmedicated obsessive-compulsive disorder. World J Psychiatry 2025; 15(8): 107860
URL: https://www.wjgnet.com/2220-3206/full/v15/i8/107860.htm
DOI: https://dx.doi.org/10.5498/wjp.v15.i8.107860

Zhang ZF, He Y, Su YQ, Liu JM. Decreased inter- and intra-network connectivity after group cognitive behavioral therapy in patients with unmedicated obsessive-compulsive disorder. World J Psychiatry 2025; 15(8): 107860 [PMID: 40837793 DOI: 10.5498/wjp.v15.i8.107860]

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